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dc.creatorBehrens P,María Isabel
dc.creatorDíaz T,Violeta
dc.creatorVásquez V,Carolina
dc.creatorDonoso S,Archibaldo
dc.date2003-08-01
dc.date.accessioned2019-11-14T12:59:15Z
dc.date.available2019-11-14T12:59:15Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000800012
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/119368
dc.descriptionCyanocobalamin (vitamin B12) deficiency can cause polyneuropathy, myelopathy, blindness, confusion, psychosis and dementia. Nonetheless, its deficiency as the sole cause of dementia is infrequent. We report a 59 years old man with a 6 months history of progressive loss of memory, disorientation, apathy, paranoid delusions, gait difficulties with falls, and urinary incontinence. He had suffered a similar episode 3 years before, with a complete remission. On examination there was frontal type dementia with Korsakoff syndrome, a decrease in propioception and ataxic gait. Cerebrospinal fluid examination showed a protein of 0.42 g/L. Brain computed tomography showed sequelae of a frontal left trauma. Brain single photon computed tomography (SPECT) was normal. Complete blood count showed a macrocytic anemia with a hematocrit 29% and a mean corpuscular volume of 117 µ3. Plasma vitamin B12 levels were undetectable, erythrocyte folate levels were 3.9 ng/ml and plasma folate was normal. The myelogram showed megaloblastosis and the gastric biopsy showed atrophic gastritis. Treatment with parenteral B12 vitamin and folic acid reverted the symptoms, with normalization of the neuropsychological tests and reintegration to work (Rev Méd Chile 2003; 131: 915-9)
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dc.languagees
dc.publisherSociedad Médica de Santiago
dc.relation10.4067/S0034-98872003000800012
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista médica de Chile v.131 n.8 2003
dc.subjectDementia
dc.subjectTomography
dc.subjectemiss on computed
dc.subjectsingle photon
dc.subjectVitamin B12 deficiency
dc.titleDemencia por déficit de vitamina B12: Caso clínico


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