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dc.creatorRoa E,Iván
dc.creatorIbacache S,Gilda
dc.creatorCarvallo B,Julio
dc.creatorMelo S,Angélica
dc.creatorAraya O,Juan
dc.creatorDe Aretxabala U,Xabier
dc.creatorFigueroa P,Miguel
dc.creatorBarrientos C,Fernando
dc.creatorFigueroa Z,Carlos
dc.date1999-09-01
dc.date.accessioned2020-02-17T15:25:05Z
dc.date.available2020-02-17T15:25:05Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98871999000900003
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/125890
dc.descriptionBackground: Gallbladder cancer is frequent in Chile and there is sparse information about the association between this type of cancer and the presence of bacteria in the gallbladder bile. Aim: To determine the presence of aerobic bacteria in gallbladder bile in patients with and without gallbladder cancer. Material and methods: A microbiological analysis of bile and pathological study was performed in 608 gallbladders, obtained during to cholecystectomies performed to 513 women and 95 men aged 44 years old as a mean. Results: Pathological study showed a chronic cholecystitis in 468 cases (77%), an acute cholecystitis in 140 (33%), cancer in 24 (3.9%) and dysplasia in 5 cases (0.8%). A positive culture was obtained in 22.5% of women and 28.5% of males. Twenty seven percent of women over 30 years old had positive cultures compared with 10% of younger women (p <0.001). Thirty two percent of acute cholecystitis had positive cultures, compared with 24% of chronic cholecystitis (p=0.03). E Coli was isolated in 51% of positive cases, Streptococci-Enterococci in 24%, Enterobacter sp in 9%, Klebsiella and Proteus in lower proportions. Salmonella sp was isolated in 4 cases, being all women with chronic cholecystitis. Thirteen of 29 cases with cancer or dysplasia had positive cultures (45%), compared with 25% of patients with inflammatory gallbladder diseases (p=0.02). Streptococci-Enterococci were isolated in 7 cases and Enterobacter sp in three. Conclusions: The presence of Salmonella sp in gallbladder bile was not frequent in the studied patients. Its role in the pathogenesis of gallbladder cancer must be reassessed.
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dc.publisherSociedad Médica de Santiago
dc.relation10.4067/S0034-98871999000900003
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista médica de Chile v.127 n.9 1999
dc.subjectBacterial infectious
dc.subjectBile
dc.subjectBiliary tract surgery
dc.subjectGallbladder neoplasms
dc.titleEstudio bacteriológico de la bilis vesicular en un área de alto riesgo de cáncer vesicular


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