| dc.creator | Jirón V,M. Isabel | |
| dc.creator | Ardiles S,Adriana | |
| dc.creator | Parra B,M Adriana | |
| dc.creator | Orellana V,Juana | |
| dc.date | 2000-03-01 | |
| dc.date.accessioned | 2020-02-17T15:25:25Z | |
| dc.date.available | 2020-02-17T15:25:25Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000300004 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/126097 | |
| dc.description | Background: Anti liver kidney microsome antibodies (LKM-1) have been recently incorporated to the study and classification of chronic autoimmune hepatitis (HC-A1). The presence of anti LKM-1 antibodies and essential cryoglobulinemia is frequent in virus C associated chronic hepatitis (HC-VC). Aim: To study the frequency of anti LKM-1 antibodies and cryoglobulin levels in patients with HC-AI, HC-VC and cryptogenic cirrhosis. Patients and methods: Forty two patients were studied. Nineteen adult women with classic HC-AI with positive antinuclear or anti smooth muscle antibodies. Five patients of less than 20 years old with HC-AI and negative antinuclear and anti smooth muscle antibodies. Ten adult women with cryptogenic cirrhosis, 4 women and 4 men with HC-VC. Serum samples were obtained at 37°C. Antinuclear, anti smooth muscle and anti LKM-1 antibodies were measured by indirect immunofluorescence using Hep-2 cells and rat tissue slices as substrates. Cryoglobulins were determined by the traditional method and cryocrit. Results: All studied patients were anti LKM-1 negative. All had significant circulating cryoglobulin levels. Conclusions: In this sample of patients with HC-AI or HC-VC, anti LKM-1 antibodies were not detected but all had cryoglobulinemia | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.relation | 10.4067/S0034-98872000000300004 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Revista médica de Chile v.128 n.3 2000 | |
| dc.subject | Cryoglobulinemia | |
| dc.subject | Hepatitis | |
| dc.subject | autoimmune | |
| dc.subject | Hepatitis C | |
| dc.subject | chronic | |
| dc.subject | Liver cirrhosis | |
| dc.title | Anticuerpos anti LKM-1 y crioglobulinemia en hepatitis crónica autoinmune y por virus C de la hepatitis | |
