| dc.creator | ROJO,DANIEL | |
| dc.creator | SUETOMI,KATSUTOSHI | |
| dc.creator | NAVARRO,JAVIER | |
| dc.date | 1999-01-01 | |
| dc.date.accessioned | 2020-02-17T15:25:51Z | |
| dc.date.available | 2020-02-17T15:25:51Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97601999000400006 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/126372 | |
| dc.description | Chemokine receptors are G protein-coupled receptors that mediate migration and activation of leukocytes as an important part of a protective immune response to injury and infection. In addition, chemokine receptors are used by HIV-1 to infect CD4 positive cells. The structural bases of chemokine receptor recognition and signal transduction are currently being investigated. High-resolution X-ray diffraction and NMR spectroscopy of chemokines indicate that all these peptides exhibit a common folding pattern, in spite of its low degree of primary-sequence homology. Chemokines' functional motifs have been identified by mutagenesis studies, and a possible mechanism for receptor recognition and activation is proposed, but high-resolution structure data of chemokine receptors is not yet available. Studies with receptor chimeras have identified the putative extracellular domains as the major selectivity determinants. Single-amino acid substitutions in the extracellular domains produce profound changes in receptor specificity, suggesting that motifs in these domains operate as a restrictive barrier to a common activation motif. Similarly HIV-1 usage of chemokine receptors involves interaction of one or more extracellular domains of the receptor with conserved and variable domains on the viral envelope protein gp 120, indicating a highly complex interaction. Elucidating the structural requirements for receptor interaction with chemokines and with HIV-1 will provide important insights into understanding the mechanisms of chemokine recognition and receptor activation. In addition, this information can greatly facilitate the design of effective inmunomodulatory and anti-HIV-1 therapeutic agents | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97601999000400006 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.32 n.4 1999 | |
| dc.subject | Chemokines | |
| dc.subject | G-protein coupled receptors | |
| dc.subject | Inflammation | |
| dc.subject | HIV-1 | |
| dc.title | Structural biology of chemokine receptors | |
