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dc.creatorITURRIAGA,RODRIGO
dc.date2001-01-01
dc.date.accessioned2020-02-17T15:27:07Z
dc.date.available2020-02-17T15:27:07Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200019
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/127153
dc.descriptionNitric oxide (NO) has been proposed as an inhibitory modulator of carotid body chemosensory responses to hypoxia. It is believed that NO modulates carotid chemoreception by several mechanisms, which include the control of carotid body vascular tone and oxygen delivery and reduction of the excitability of chemoreceptor cells and petrosal sensory neurons. In addition to the well-known inhibitory effect, we found that NO has a dual (dose-dependent) effect on carotid chemoreception depending on the oxygen pressure level. During hypoxia, NO is primarily an inhibitory modulator of carotid chemoreception, while in normoxia NO increased the chemosensory activity. This excitatory effect produced by NO is likely mediated by an impairment of mitochondrial electron transport and oxidative phosphorylation, which increases the chemosensory activity. The recent findings that mitochondria contain an isoform of NO synthase, which produces significant amounts of NO for regulating their own respiration, suggest that NO may be important for the regulation of mitochondrial energy metabolism and oxygen sensing in the CB.
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602001000200019
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.34 n.2 2001
dc.subjectCarotid body
dc.subjectchemoreceptor
dc.subjectcytochrome oxidase
dc.subjecthypoxia
dc.subjectnitric oxide
dc.subjectoxidative phosphorylation
dc.titleNitric oxide and carotid body chemoreception


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