| dc.creator | PETERSEN,OLE H. | |
| dc.date | 2002-01-01 | |
| dc.date.accessioned | 2020-02-17T15:28:42Z | |
| dc.date.available | 2020-02-17T15:28:42Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200008 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/128083 | |
| dc.description | Cytosolic calcium signals are produced by suddenly increasing the concentration of free calcium ions (Ca2+). This can occur by opening channels permeable to Ca2+ either in the surface cell membrane or in the membranes of intracellular organelles containing high Ca2+ concentrations. Ca2+ signals can control several different processes, even in the same cell. In pancreatic acinar cells, for example, Ca2+ signals do not only control the normal secretion of digestive enzymes, but can also activate autodigestion and programmed cell death. Recent technical advances have shown that different patterns of Ca2+ signals can be created, in space and time, which allow specific cellular responses to be elicited. The mechanisms responsible for Ca2+ signal compartmentalization are now largely known and will be described on the basis of recent studies of Ca2+ transport pathways and their regulation in pancreatic acinar cells. It turns out that the Ca2+ handling as well as the structural characteristics of the endoplasmic reticulum (ER) and the mitochondria are of particular importance. Using a variety of Ca2+-sensitive fluorescent probes placed in different sub-cellular compartments in combination with local uncaging of caged Ca2+, many new insights into Ca2+ signal generation, compartmentalization and termination have recently been obtained | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602002000200008 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.35 n.2 2002 | |
| dc.subject | Calcium signals | |
| dc.subject | Ca2+ release channels | |
| dc.subject | Ca2+ pumps | |
| dc.subject | endoplasmic reticulum | |
| dc.subject | mitochondria | |
| dc.subject | pancreatic acinar cell | |
| dc.subject | pancreatitis, secretion | |
| dc.subject | apoptosis | |
| dc.title | Calcium signal compartmentalization | |
