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dc.creatorMENNICKENT,SIGRID
dc.creatorMARIO,VEGA
dc.creatorGODOY,CARMEN GLORIA
dc.date2003-09-01
dc.date.accessioned2020-02-17T15:31:23Z
dc.date.available2020-02-17T15:31:23Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-97072003000300014
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/129614
dc.descriptionAn instrumental planar chromatography method for quantitative analysis of carbamazepine in saliva was developed. The linearity, precision, detection and quantification limits, accuracy and selectivity of the method were validated. The method was linear between 0.50 and 15.00 ng/spot, with a regression coefficient of 0.999. The intra-assay variation (repeatability) was between 5.1% and 7.4%, and the inter-assay (reproducibility) was between 5.6% and 7.4%. The detection limit was 0.18 ng, and the quantification limit was 0.54 ng. The method proved accurate, with a recovery percentage of 109.8%, and it was selective for the active principle tested. In conclusion, is a good method for the quantitative determination of carbamazepine in saliva
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Química
dc.relation10.4067/S0717-97072003000300014
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceJournal of the Chilean Chemical Society v.48 n.3 2003
dc.subjectcarbamazepine
dc.subjectHPTLC (high performance thin layer chromatography or instrumental thin layer chromatography or instrumental planar chromatography)
dc.subjectquantitative analysis
dc.subjectsaliva
dc.subjectanalytical parameters
dc.subjectdrugs
dc.subjectepilepsy
dc.titleDEVELOPMENT AND VALIDATION OF A METHOD USING INSTRUMENTAL PLANAR CHROMATOGRAPHY FOR QUANTITATIVE ANALYSIS OF CARBAMAZEPINE IN SALIVA


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