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ESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGS

dc.creatorOlea-Azar,Claudio
dc.creatorRigol,Carolina
dc.creatorOpazo,Lucía
dc.creatorMorello,Antonio
dc.creatorMaya,Juan Diego
dc.creatorRepetto,Yolanda
dc.creatorAguirre,Gabriela
dc.creatorCerecetto,Hugo
dc.creatorDi Maio,Rossanna
dc.creatorGonzález,Mercedes
dc.creatorPorca,Williams
dc.date2003-12-01
dc.date.accessioned2020-02-17T15:31:58Z
dc.date.available2020-02-17T15:31:58Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-97072003000400012
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/129941
dc.descriptionThe Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation of free radicals in the trypanosome microsomal system. The Nitro 2 (4-(n-butyl)-1-(5-nitrofurfurylidene)semicarbazide) analogue of Nifurtimox showed better antiparasitic activity than N-oxide 1 (4-(n-butyl)-1-[(7-bromo-N1-oxidebenzo[1,2-c]1,2,5-oxadiazole-5-yl)methylidene]semicarbazide). Only Nitro 2 could produce oxygen redox cycling in T. cruzi epimastigotes. The ESR signal intensities were consistent with the trapping of hydroxyl radical. These results are in agreement with the biological observation that Nitro 2 showed antichagasic activity by an oxidative stress mechanism
dc.formattext/html
dc.languageen
dc.publisherSociedad Chilena de Química
dc.relation10.4067/S0717-97072003000400012
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceJournal of the Chilean Chemical Society v.48 n.4 2003
dc.subjectNitrofuran derivatives
dc.subjectN-Oxide derivatives
dc.subjectROS scavenging
dc.subjectESR spin trapping
dc.subjectT. cruzi
dc.subjectoxidative stress
dc.titleESR AND SPIN TRAPPING STUDIES OF TWO NEW POTENTIAL NTITRYPANOSOMAL DRUGS


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