| dc.creator | Tapia P,Cecilia | |
| dc.creator | González A,Patricia | |
| dc.creator | Pereira A,Angélica | |
| dc.creator | Pérez G,Jorge | |
| dc.creator | Noriega R,Luis M | |
| dc.creator | Palavecino R,Elizabeth | |
| dc.date | 2003-05-01 | |
| dc.date.accessioned | 2020-02-17T15:33:31Z | |
| dc.date.available | 2020-02-17T15:33:31Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000500006 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/130807 | |
| dc.description | Background: Oropharyngeal candidiasis (OPC) and esophageal candidiasis (EPC) are frequent complications in AIDS patients. The use of Fluconazole, an effective and a low toxicity drug, has been associated to the emergency of secondary resistant strains. For this reason, in vitro antifungal susceptibility tests are necessary to predict a therapeutic failure. Etest® is an easy to perform alternative test, that has showed a good agreement with the broth microdilution reference method (NCCLS, document M27-A). Aim: To measure the susceptibility of C. albicans isolates from AIDS patients complicated with OPC and EPC to Amphotericin B (AmB) and Fluconazole (Flu) using Etest®. Material and methods: Twenty strains from 20 AIDS patients were studied. AmB was tested in RPMI 1640 agar and Flu in Casitone agar. Results: All studied strains showed minimal inhibitory concentrations (MICs) <1 mg/mL for AmB. A highly resistant strain to Flu (>256 mg/mL) was isolated from a patient previously treated with Flu. Conclusions: In AIDS patients with OPC and EPC, the susceptibility to Flu of the isolates should be screened, to detect resistant strains. Etest®; is a reliable alternative in these cases, for laboratories that cannot use the reference method (Rev Méd Chile 2003; 131: 515-19). | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.relation | 10.4067/S0034-98872003000500006 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Revista médica de Chile v.131 n.5 2003 | |
| dc.subject | Acquired immunodeficiency syndrome | |
| dc.subject | Amphotericin B | |
| dc.subject | Candida albicans | |
| dc.subject | Fluconazole | |
| dc.title | Susceptibilidad antifúngica de Candida albicans recuperadas de pacientes con SIDA y candidiasis orofaríngea y esofágica: Experiencia con Etest® | |
