| dc.creator | Casanueva E,Víctor | |
| dc.creator | Cid C,Ximena | |
| dc.creator | Cancino M,Matilde | |
| dc.creator | Borzone T,Laura | |
| dc.creator | Cid S,Luis | |
| dc.date | 2003-09-01 | |
| dc.date.accessioned | 2020-02-17T15:33:39Z | |
| dc.date.available | 2020-02-17T15:33:39Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872003000900005 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/130878 | |
| dc.description | Hyperhomocysteinemia is an independent cardiovascular risk factor that depends on folate and vitamin B12 nutrition. Aim: To measure homocysteine, folic acid and vitamin B12 serum levels in healthy children with and without a family history of cardiovascular disease. Subjects and methods: Forty children aged 6 to 15 years with a family history of cardiovascular disease, and 40 age and sex matched children without such history were studied. Serum homocysteine, folic acid and vitamin B12 were measured in a fasting blood sample. Homocysteine was measured by a fluorescence polarization immunoassay (FPIA), vitamin B12 by enzymatic microparticle assay, covered with intrinsic factor and folic acid by ionic capture, using commercial kits. Results: Children with family history of cardiovascular disease had higher homocysteine levels than their counterparts without family history (7.9±3 and 5.8±2 µmol/l respectively, p <0.03), but similar folic acid (5.2±1.8 and 5.5±1.4 pg/ml respectively) and vitamin B12 levels (431±213 and 445±209 ng/ml respectively). There was a negative and significant correlation between homocysteine and folic acid and vitamin B12 levels. Conclusions: Children with a family history of cardiovascular disease have higher levels of serum homocysteine than those without such history, despite having similar levels of folic acid and vitamin B12 | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.relation | 10.4067/S0034-98872003000900005 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Revista médica de Chile v.131 n.9 2003 | |
| dc.subject | Cardiovascular diseases | |
| dc.subject | Folic acid | |
| dc.subject | Homocysteine | |
| dc.subject | Risk factors | |
| dc.subject | Vitamin B12 | |
| dc.title | Homocisteína en niños y adolescentes. Relación con historia familiar de enfermedad cardiovascular | |
