| dc.creator | Roa E,Iván | |
| dc.creator | Aretxabala U,Xabier de | |
| dc.creator | Fuentealba A,Patricia | |
| dc.creator | Cabrera C,María Elena | |
| dc.creator | Araya O,Juan C | |
| dc.creator | Roa S,Juan | |
| dc.date | 2004-07-01 | |
| dc.date.accessioned | 2020-02-17T15:33:44Z | |
| dc.date.available | 2020-02-17T15:33:44Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872004000700002 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/130931 | |
| dc.description | Background: The clinical and morphological characterization of the subserous gallbladder carcinomas is controversial. Aim: To study the prognostic importance of DNA content of subserous gallbladder carcinoma. Material and methods: We studied 104 females aged 60±12 years old and 16 men aged 70±13 years old. In all of them diagnosis was established after mapping of cholecystectomy sample and had a complete clinical follow up. DNA content was measured by flow cytometry. Results: All tumors were adenocarcinoma, and only 16% were well differentiated. Aneuploidy was observed in 29 cases (26%) with DNA index fluctuating between 1.1 and 1.8. Lymphatic vessel tumor involvement was present in 16 of 22 cases with aneuploidy and in 22 of 46 diploid tumors (p= 0.05). Eighty nine percent of aneuploid tumors were detected macroscopically and 11% were unapparent. Five years survival was non significantly better among patients with diploid tumors than in patients with aneuploid tumors (45 and 28%, respectively, p= 0.2). The histological differentiation was the only variable significantly associated with survival. Conclusions: Aneuploidy is present in 26% of subserous gallbladder carcinoma. It is not related with any of the morphological or clinical variables studied in this series of patients (Rev Méd Chile 2004; 132: 794-800) | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.relation | 10.4067/S0034-98872004000700002 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Revista médica de Chile v.132 n.7 2004 | |
| dc.subject | Adenocarcinoma | |
| dc.subject | DNA, neoplasm | |
| dc.subject | Gallbladder neoplasms | |
| dc.title | Contenido de ADN y sobrevida en el carcinoma subseroso de la vesícula biliar | |
