| dc.creator | KAPLAN,MARIELLE | |
| dc.creator | AVIRAM,MICHAEL | |
| dc.date | 2004-01-01 | |
| dc.date.accessioned | 2020-02-17T15:34:03Z | |
| dc.date.available | 2020-02-17T15:34:03Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000200010 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/131107 | |
| dc.description | Proteoglycans (PGs) from the arterial extracellular matrix (ECM) contribute to the trapping of LDL and oxidized LDL (Ox-LDL) in the arterial wall, a phenomenon called "lipoprotein retention". Moreover, we have shown that subsequent to their binding to the matrix, LDL and Ox-LDL are taken up by macrophages. Oxidative stress significantly increases macrophage secretion of ECM-PGs, lipoprotein binding to the ECM and the uptake of ECM-retained lipoproteins by macrophages. The aim of the present study was to determine whether red wine administration to atherosclerotic mice would affect their peritoneal macrophage-derived extracellular matrix properties, such as the glycosaminoglycan content and the ability to bind LDL. In addition, we questioned the ability of LDL bound to the mice peritoneal macrophages-derived ECM to be taken up by macrophages. Red wine administration to atherosclerotic mice did not affect the mice peritoneal macrophages-derived ECM glycosaminoglycan content but it significantly reduced the mice peritoneal macrophages-derived ECM ability to bind LDL and the subsequent uptake of ECM-retained LDL by the macrophages. The present study thus clearly demonstrated the inhibitory effect of red wine consumption by E0 mice on their peritoneal macrophage-derived extracellular matrix atherogenic properties. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602004000200010 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.37 n.2 2004 | |
| dc.subject | Antioxidants | |
| dc.subject | atherosclerosis | |
| dc.subject | extracellular matrix | |
| dc.subject | macrophages | |
| dc.subject | polyphenols | |
| dc.subject | proteoglycans | |
| dc.subject | red wine | |
| dc.title | Red Wine administration to Apolipoprotein E-deficient Mice reduces their Macrophage-derived Extracellular Matrix Atherogenic Properties | |
