| dc.creator | Araya O,Juan Carlos | |
| dc.creator | Anabalón R,Leonardo | |
| dc.creator | Roa E,Iván | |
| dc.creator | Bravo E,María | |
| dc.creator | Villaseca H,Miguel Ángel | |
| dc.creator | Guzmán G,Pablo | |
| dc.creator | Roa S,Juan Carlos | |
| dc.date | 2004-11-01 | |
| dc.date.accessioned | 2020-02-17T15:34:06Z | |
| dc.date.available | 2020-02-17T15:34:06Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872004001100002 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/131145 | |
| dc.description | Background: The damaging capacity of Helicobacter pylori is variable and depends, in part, on its genetic polymorphism. Aim: To study H pylori genes vacA, cagA and iceA and the relationship of these genotypes with the features of acute damage in chronic gastritis. Material and methods: Gastric endoscopic biopsies were obtained in 75 adults for pathological study and genetic typification of H pylori by specific PCR. Results: In only 64 cases, complete information was available. In 53 of these, there was H pylori infection demonstrated by PCR. Twenty one percent had infection by two or more H pylori strains, vacA gene had genotypes s2/m2, s1/m1 and s1/m2 in 36, 25 and 8% of cases respectively, cagA gene was present in 49% of infected patients. iceA gene had genotypes iceA 1 ad iceA 2 in 15 and 60% of patients respectively. The presence of cagA or alleles s1/m1 and s1/m2 of vacA gene was directly correlated with polymorphonuclear infiltration and the severity of epithelial damage. The genotype s2/m2 of vacA gene was significantly associated with a milder or absent mucosal damage. No association was found between iceA alleles and the pathological features of gastritis. Conclusions: Alleles of vacA and cagA genes of H pilory are associated with the severity of gastric mucosal damage | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.relation | 10.4067/S0034-98872004001100002 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Revista médica de Chile v.132 n.11 2004 | |
| dc.subject | Gastritis | |
| dc.subject | Genes | |
| dc.subject | bacterial | |
| dc.subject | Helicobacter pylori | |
| dc.title | Relación de la genotipificación de Helicobacter pylori con la forma e intensidad de la gastritis en población adulta portadora de patología gástrica benigna | |
