| dc.creator | Afani S,Alejandro | |
| dc.creator | Ayala C,Marisol | |
| dc.creator | Meyer K,Andrea | |
| dc.creator | Cabrera C,Roy | |
| dc.creator | Acevedo M,William | |
| dc.date | 2005-03-01 | |
| dc.date.accessioned | 2020-02-17T15:35:13Z | |
| dc.date.available | 2020-02-17T15:35:13Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000300004 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/131773 | |
| dc.description | Background: Resistance to antiretroviral therapy is a determining factor for therapeutic failure in HIV/AIDS. The prevalence of primary resistance (i.e. in those patients that have not received treatment) varies in different parts of the world. Aim: To study the prevalence of primary resistance to antiretroviral drugs in patients living in Northern Santiago. Patients and methods: Viral load, lymphocyte subpopulations by flow cytometry and genotypic resistance testing were assessed in blood samples from 60 HIV-1 infected patients (mean age 37 years, 54 male). Results: Mean CD4 cell count and viral load was 200 cells/ml and 142,840 RNA copies/ml respectively. Ten mutations were identified: V179D, L10I/V, M361, L63P, A71T/V, Y115F, V118I and K20R. None of these mutations is associated to a high degree of resistance to reverse transcriptase inhibitors, nucleoside analogs (NRTI), non nucleoside analogs (NNRTI) or viral protease inhibitors. Conclusions: This is a first approach to study antiretroviral resistance in Chilean patients. This study must be amplified, since the prevalence of resistance may experience changes with time (Rev Méd Chile 2005; 133: 295-301) | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.relation | 10.4067/S0034-98872005000300004 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Revista médica de Chile v.133 n.3 2005 | |
| dc.subject | Acquired immunodeficiency syndrome | |
| dc.subject | Antiretroviral therapy, highly active | |
| dc.subject | HIV infections | |
| dc.title | Resistencia primaria a terapia antirretroviral en pacientes con infección por VIH/SIDA en Chile | |
