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dc.creatorAfani S,Alejandro
dc.creatorAyala C,Marisol
dc.creatorMeyer K,Andrea
dc.creatorCabrera C,Roy
dc.creatorAcevedo M,William
dc.date2005-03-01
dc.date.accessioned2020-02-17T15:35:13Z
dc.date.available2020-02-17T15:35:13Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000300004
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/131773
dc.descriptionBackground: Resistance to antiretroviral therapy is a determining factor for therapeutic failure in HIV/AIDS. The prevalence of primary resistance (i.e. in those patients that have not received treatment) varies in different parts of the world. Aim: To study the prevalence of primary resistance to antiretroviral drugs in patients living in Northern Santiago. Patients and methods: Viral load, lymphocyte subpopulations by flow cytometry and genotypic resistance testing were assessed in blood samples from 60 HIV-1 infected patients (mean age 37 years, 54 male). Results: Mean CD4 cell count and viral load was 200 cells/ml and 142,840 RNA copies/ml respectively. Ten mutations were identified: V179D, L10I/V, M361, L63P, A71T/V, Y115F, V118I and K20R. None of these mutations is associated to a high degree of resistance to reverse transcriptase inhibitors, nucleoside analogs (NRTI), non nucleoside analogs (NNRTI) or viral protease inhibitors. Conclusions: This is a first approach to study antiretroviral resistance in Chilean patients. This study must be amplified, since the prevalence of resistance may experience changes with time (Rev Méd Chile 2005; 133: 295-301)
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dc.languagees
dc.publisherSociedad Médica de Santiago
dc.relation10.4067/S0034-98872005000300004
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista médica de Chile v.133 n.3 2005
dc.subjectAcquired immunodeficiency syndrome
dc.subjectAntiretroviral therapy, highly active
dc.subjectHIV infections
dc.titleResistencia primaria a terapia antirretroviral en pacientes con infección por VIH/SIDA en Chile


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