| dc.creator | VERKHRATSKY,ALEXEI | |
| dc.date | 2004-01-01 | |
| dc.date.accessioned | 2020-02-17T15:35:45Z | |
| dc.date.available | 2020-02-17T15:35:45Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400027 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/132058 | |
| dc.description | The endoplasmic reticulum (ER) is an important organelle involved in various types of signaling in nerve cells. The ER serves as a dynamic Ca2+ pool being thus involved in rapid signaling events associated with cell stimulation by either electrical (action potential) or chemical (neurotransmitters) signals. This function is supported by Ca2+ release channels (InsP3 and ryanodine receptors) and SERCA Ca2+ pumps residing in the endomembrane. In addition the ER provides a specific environment for the posttranslational protein processing and transport of various molecules towards their final destination. In parallel, the ER acts as a "calcium tunnel," which facilitates Ca2+ movements within the cell by avoiding cytoplasmic routes. Finally the ER appears as a source of numerous signals aimed at the nucleus and involved in long-lasting adaptive cellular responses. All these important functions are controlled by intra-ER free Ca2+ which integrates various signaling events and establishes a link between fast signaling, associated with ER Ca2+ release/uptake, and long-lasting adaptive responses relying primarily on the regulation of protein synthesis. Disruption of ER Ca2+ homeostasis triggers several forms of cellular stress response and is intimately involved in neurodegeneration and neuronal cell death | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602004000400027 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.37 n.4 2004 | |
| dc.subject | calcium signaling | |
| dc.subject | endoplasmic reticulum | |
| dc.subject | ryanodine receptors | |
| dc.subject | InsP3 receptors | |
| dc.title | Endoplasmic reticulum calcium signaling in nerve cells | |
