Estudio de la actividad comparativa in vitro de telitromicina en patógenos respiratorios adquiridos en la comunidad en 13 centros clínicos chilenos
Author
Ulloa F,María T
Camponovo C,Rossanna
Fernández V,Alejandra
García C,Patricia
Prado J,Valeria
González A,Patricia
Rojas S,Pamela
Inostroza S,Jaime
Lafourcade R,Mónica
Aguilera A,Liliana
Porte T,Lorena
Cruz P,Carolina
Joyas M,Alejandro
Alcaide L,Berta
Pinto C,María E
Giglio M,María S
Abstract
Background: Telithromycin is a new ketolide antimicrobial, that can be useful for the treatment of respiratory infections. Aim: To compare in vitro activity of telithromycin against respiratory pathogens, isolated in outpatient clinics. Material and methods: Two hundred eighty strains isolated from patients with respiratory infections, were studied. The strains studied were S pneumoniae, penicillin sensitive (SPNS:57); intermediate (SPNI:35), resistant (SPNR:25); S pyogenes (SP:57); H influenzae (HIN 51); M catarrhalis (MC:25) and S aureus meticillin sensitive (SAUS:30). Minimal inhibitory concentration (MIC) by broth microdilution was studied for telitrhomycin and levofloxacin in all strains. Other antimicrobials studied, but not in all strains were erythromycin, clindamycin, trimetoprim sulphamethoxazole, oxacillin, amoxicillin-clavulanic acid and cefuroxime. Results: All strains were sensible to telithromycin at a concentration 4 µg/ml. MIC 90 and its range for SPNS was 0.03 µg/ml (0.004-0.12), for SPNI was 0.03 µg/ml (0.004-025), for SPNR was 0.06 µg/ml (0.004-0.25), for HIN was 2 µg/ml (0.12-4), for SP was 0.5 µg/ml (0.004-2), for MC was 0.5 µg/ml (0.06-2) and for SAU was 0.25 µg/ml (0.06-0.25). Conclusions: All studied pathogens were sensible to telithromycin in vitro. This antimicrobial is an alternative for the treatment of community acquired respiratory infections