dc.creator | Romanque U,Pamela | |
dc.creator | Uribe M,Mario | |
dc.creator | Videla,Luis A | |
dc.date | 2005-04-01 | |
dc.date.accessioned | 2020-02-17T15:35:56Z | |
dc.date.available | 2020-02-17T15:35:56Z | |
dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872005000400012 | |
dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/132152 | |
dc.description | Ischemia-reperfusion (IR) liver injury is associated with temporary clamping of hepatoduodenal ligament during liver surgery, hypoperfusion shock and graft failure after liver transplantation. Mechanisms of IR liver injury include: i) loss of calcium homeostasis, ii) reactive oxygen and nitrogen species generation, iii) changes in microcirculation, iv) Kupffer cell activation, and (v) complement activation. Pre-exposure of the liver to transient ischemia increases the tolerance to IR injury, a phenomenon known as hepatic ischemic preconditioning (IP). IP involves: i) recovery of the energy supply and calcium, sodium and pH homeostasis, ii) enhancement in the antioxidant potential, and iii) expression of multiple stress-response proteins, including acute phase proteins, heat shock proteins, and heme oxygenase. These observations and preliminary studies in humans give a rationale for the assessment of IP in minimizing or preventing IR injury during surgery and non surgical conditions of tissue hypoperfusion | |
dc.format | text/html | |
dc.language | es | |
dc.publisher | Sociedad Médica de Santiago | |
dc.relation | 10.4067/S0034-98872005000400012 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.source | Revista médica de Chile v.133 n.4 2005 | |
dc.subject | Ischemia-reperfusion injury | |
dc.subject | Liver transplantation | |
dc.subject | Shock, surgical | |
dc.title | Mecanismos moleculares en el daño por isquemia-reperfusión hepática y en el preacondicionamiento isquémico | |