Comparative evaluation of micronuclei in Saudi smokers and non-smokers without any visible oral lesions– A pilot study.
Evaluación comparativa de micronúcleos en fumadores y no fumadores sauditas sin lesiones orales visibles- Un estudio piloto.;
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| dc.creator | Ganji, Kiran Kumar | |
| dc.creator | Manay, Srinivas Munisekhar | |
| dc.creator | Muqbeel, Fahad | |
| dc.creator | Khalaf, Hamad | |
| dc.creator | Tami, Naif | |
| dc.creator | Ibrahim, Hassan | |
| dc.creator | Alam, MohammadX Khursheed | |
| dc.date | 2020-02-08 | |
| dc.identifier | http://www.joralres.com/index.php/JOR/article/view/joralres.2019.074 | |
| dc.identifier | 10.17126/joralres.2019.074 | |
| dc.description | Objectives: A systematic review was conducted to evaluate effectiveness and safety of beta carotenes for the treatment of oral leukoplakia regarding clinical resolution and prevention of malignant transformation. Material and Methods: The systematic search was conducted in three electronic databases and the study’s selection was performed according to pre-set eligibility criteria. Four studies evaluating the efficacy of beta carotenes in oral leukoplakia compared to placebo were included in the review; three of which were assigned for quantitative analysis. Data were extracted, tabulated, quality assessed and statistically analyzed. Results: The meta-analysis revealed that when comparing clinical resolution the beta carotene group favored was favored compared to placebo, with statistically significant difference. However, a meta-analysis comparing beta carotene and placebo groups regarding malignant transformation as a primary outcome failed to show any significant benefit. Furthermore, results showed evidence of beta carotene safety. Conclusion: the overall quality of evidence about efficacy of beta carotene in oral leukoplakia treatment was not high. However, given the obvious safety of this agent, data suggests it could have a promising effect in clinical improvement of oral leukoplakia lesions. However, no evidence supporting its benefits in reducing risk of malignant transformation in these lesions was found. Therefore, further long term, well designed randomized clinical trials are highly recommended. | en-US |
| dc.description | Introducción: el cáncer oral es un problema grave con alta mortalidad y morbilidad, a pesar de la disponibilidad de los mejores tratamientos. Uno de los factores más importantes para una mortalidad tan alta es su diagnóstico tardío. La mejor manera de enfrentar un problema de este tipo es evitar su aparición creando conciencia entre la población y tenendo un diagnóstico más temprano. El cáncer oral es una enfermedad multifactorial, donde el daño genómico tiene un papel. Se ha demostrado que los micronúcleos (MNi) son un biomarcador importante y en este estudio se utilizó como una herramienta para crear conciencia sobre el riesgo de cáncer oral. Objetivo: evaluar y comparar la frecuencia de MNi en fumadores sin ninguna lesión oral visible (Grupo I) y no fumadores sanos (Grupo II). Materiales y métodos: se obtuvieron citoestimuladores de fumadores sauditas (n = 15, Grupo I) sin ninguna lesión oral visible y no fumadores sanos (n = 15, control, Grupo II) y se tiñeron con hemotoxilina y eosina para evaluar la frecuencia de MNi y las observaciones fueron sometidas a análisis estadístico utilizando la prueba t de Student. Resultados: La frecuencia media de MNi en el Grupo I fue significativamente mayor (p<0.05) que en el Grupo II. El estudio ayuda a educar, motivar y crear conciencia, alentando así a los pacientes a dejar de fumar, y evitando así el cáncer oral antes de su inicio. | es-ES |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Facultad de Odontología, Universidad de Concepción, Chile. | en-US |
| dc.relation | http://www.joralres.com/index.php/JOR/article/view/joralres.2019.074/644 | |
| dc.rights | Copyright (c) 2020 Journal of Oral Research | en-US |
| dc.rights | http://www.joralres.com/index.php/JOR/authorDashboard/submission/973 | en-US |
| dc.source | Journal of Oral Research; Vol 8 No 6; 505-509 | es-ES |
| dc.source | Journal of Oral Research; Vol 8 No 6; 505-509 | en-US |
| dc.source | 0719-2479 | |
| dc.source | 0719-2460 | |
| dc.title | Comparative evaluation of micronuclei in Saudi smokers and non-smokers without any visible oral lesions– A pilot study. | en-US |
| dc.title | Evaluación comparativa de micronúcleos en fumadores y no fumadores sauditas sin lesiones orales visibles- Un estudio piloto. | es-ES |
| dc.title | pt-BR | |
| dc.title | pt-PT | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | Articles | en-US |
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Journal of Oral Research
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