N,N-dimethyltryptamine (DMT) is a short-acting psychotropic agent when administered parenterally and is not active orally due to its rapid degradation by monoamine oxidase enzyme type A. There is growing interest in the therapeutic potential of DMT due to recent clinical data that has shown that produces antidepressant effects in humans. It has also been found that psychedelics that possess the central structure of DMT may have value as medications and cannot simply be labeled as drugs with the potential for abuse. The incorporation of ionic liquid and tetraruthenated zinc porphyrin to glassy carbon electrode enhanced the voltammetric determination of DMT compared to the bare glassy carbon electrode. These modified electrodes showed good performance for DMT oxidation. These results translate into a low detection limit (1.75 µM), short response time, satisfactory linear concentration range, very good stability and reproducibility. Thus, his methodology can be a feasible and inexpensive way to detect DMT in water and presents potential to be applied in the detection of DMT in urine.