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ELECTROCHEMICAL, ESR, THEORETICAL STUDIES AND IN VITRO ANTI–T. CRUZI ACTIVITY OF 2-ORGANOMETALLIC-5-NITRO-BENZIMIDAZOLES

dc.creatorBarriga-González, Germán
dc.creatorOlivares-Petit, Carla
dc.creatorToro, Patricia
dc.creatorKlahn, A. Hugo
dc.creatorOlea-Azar, Claudio
dc.creatorMaya, Juan D.
dc.creatorHuentupil, Yosselin
dc.creatorArancibia, Rodrigo
dc.date2020-03-08
dc.date.accessioned2020-04-08T11:05:14Z
dc.date.available2020-04-08T11:05:14Z
dc.identifierhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1347
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/133543
dc.descriptionThe bioorganometallic compounds 2-cyrhetrenyl-5-nitro-benzimidazole (Bzn-1) and 2-ferrocenyl-5-nitro-benzimidazole (Bzn-2) have been proposed as potential anti-Trypanosoma cruzi agents. On this regard, electrochemical, electron spin resonance and biological studies were carried out. Cyclic voltammetry experiments showed the generation of nitro anion radical derivatives and a self-protonation process was observed. Nitro anion radicals generated were characterized and analyzed using electron spin resonance spectroscopy. The compounds were tested in vitro against Trypanosoma cruzi (Dm28c strain). Biological evaluation display that 2-cyrhetrenyl-5-nitro-benzimidazole (Bzn-1) was more active than its ferrocene analogue (Bzn-2) and purely organic derivate (Bzn-3), associated with the electron-withdrawing properties of the (η5-C5H4)Re(CO)3 moiety. Finally, theoretical studies were carried out in order to elucidate the correlation between organometallic fragment, nitro-reduction potentials and trypanocidal activity.en-US
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dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1347/368
dc.relationhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1347/369
dc.rightsCopyright (c) 2020 SChQen-US
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 65 No 1 (2020): Journal of the Chilean Chemical Society; 4692-4696en-US
dc.source0717-9707
dc.source0717-9324
dc.subjectOrganometallic-benzimidazolesen-US
dc.subjectCyclic voltammetryen-US
dc.subjectESRen-US
dc.subjectTrypanocidal activityen-US
dc.subjectcomputational calculationsen-US
dc.subjectDFTen-US
dc.titleELECTROCHEMICAL, ESR, THEORETICAL STUDIES AND IN VITRO ANTI–T. CRUZI ACTIVITY OF 2-ORGANOMETALLIC-5-NITRO-BENZIMIDAZOLESen-US
dc.typeinfo:eu-repo/semantics/article
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