Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations

Auad, Jordana; Cerutti, Julieta; Cooper, Laura G.; Camussone, Cecilia M.; Lozano, Natalia A.; Crespo, Francisco M.; Lozano, Alejandro

dc.creator	Auad, Jordana
dc.creator	Cerutti, Julieta
dc.creator	Cooper, Laura G.
dc.creator	Camussone, Cecilia M.
dc.creator	Lozano, Natalia A.
dc.creator	Crespo, Francisco M.
dc.creator	Lozano, Alejandro
dc.date	2018-05-25
dc.date.accessioned	2020-07-14T19:03:39Z
dc.date.available	2020-07-14T19:03:39Z
dc.identifier	http://revistas.uach.cl/index.php/australjvs/article/view/2961
dc.identifier	10.4067/S0719-81322018000200101
dc.identifier.uri	https://revistaschilenas.uchile.cl/handle/2250/143688
dc.description	Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.	en-US
dc.description	Caseous lymphadenitis is a chronic suppurative bacterial disease caused by Corynebacterium pseudotuberculosis, and it has a high prevalence among small ruminants. Different vaccine preparations have been employed to control this disease. The adjuvant used in the formulation is a critical factor for the improvement of vaccine efficacy. No commercial vaccines are available in Argentina. The aims of the present work were to compare the specific antibody response against a C. pseudotuberculosis whole cell vaccine formulated with a classical and an immunoestimulant adjuvant in pregnant goats, and to assess the transfer of vaccine-specific antibodies from the goat to the offspring through colostrum. Twenty three pregnant goats were vaccinated. The animals were randomly allocated to three groups: control, aluminum hydroxide Al(OH)3 adjuvant and a new cage-like particle adjuvant (ISPA). Antibodies (IgG) against this antigen were measured by ELISA. A robust humoral immune response was detected in vaccinated animals, with production of specific IgG. No significant differences were found between the vaccines formulated with different adjuvants. High levels of specific antibodies were detected in colostrum samples from both immunised groups, which were passively transferred from goats to offprings. No adverse local reactions in the vaccines injection sites were detected.	es-ES
dc.format	application/pdf
dc.language	eng
dc.publisher	Facultad de Ciencias Veterinarias - Universidad Austral de Chile	es-ES
dc.relation	http://revistas.uach.cl/index.php/australjvs/article/view/2961/2486
dc.rights	Derechos de autor 2018 Austral Journal of Veterinary Sciences	es-ES
dc.source	Austral Journal of Veterinary Sciences; Vol. 50 Núm. 2 (2018); 101-105	en-US
dc.source	Austral Journal of Veterinary Sciences; Vol. 50 Núm. 2 (2018); 101-105	es-ES
dc.source	0719-8132
dc.source	0719-8000
dc.title	Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations	en-US
dc.title	Humoral immune response of pregnant goats to two Corynebacterium pseudotuberculosis bacterin formulations	es-ES
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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