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SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACIN

dc.creatorRusu, Aura
dc.creatorImre, Silvia
dc.creatorMare, Anca Delia
dc.creatorLungu, Ioana-Andreea
dc.creatorPascu, Giorgiana-Andreea
dc.creatorUivarosi, Valentina
dc.date2020-09-09
dc.date.accessioned2020-09-28T11:27:42Z
dc.date.available2020-09-28T11:27:42Z
dc.identifierhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1489
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/153698
dc.descriptionA new levofloxacin derivative using silver triflate with antibacterial activity was synthesized and characterized. The new compound has been physicochemically characterized through elemental analysis, spectroscopic and thermal methods. All correlated experimental data suggested that the levofloxacin triflate was obtained. The antibacterial activity of the new compound was tested against six Gram-positive and Gram-negative bacteria. In vitro, the new compound had similar activity to levofloxacin against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae and very closed to the minimum inhibitory concentration values of levofloxacin against Staphylococcus aureus MRSA, Enterococcus faecalis, and Pseudomonas aeruginosa.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1489/394
dc.rightsCopyright (c) 2020 SChQen-US
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 65 No 3 (2020): Journal of the Chilean Chemical Society; 4857-4860en-US
dc.source0717-9707
dc.source0717-9324
dc.subjectantibacterialen-US
dc.subjectantibiotic resistanceen-US
dc.subjectlevofloxacinen-US
dc.subjectsilver triflateen-US
dc.subjecttriflateen-US
dc.titleSYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF A NEW DERIVATIVE OF LEVOFLOXACINen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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