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  • Journal of the Chilean Chemical Society
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DEVELOPMENT, COMPUTATIONAL STUDIES AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF METFORMIN HYDROCHLORIDE IN PHARMACEUTICAL FORMULATIONS

Author
Judeh, Ahmed Abu

Sarief, Abdulla

Umar, Yunusa

Ashwaq, Omar

Haque, SK Manirul

Full text
http://www.jcchems.com/index.php/JCCHEMS/article/view/1518
Abstract
Simple, fast and sensitive spectrophotometric method was developed for the determination of metformin in pharmaceutical formulations. The spectrophotometric procedure was based on the oxidation of metformin with potassium permanganate in alkaline medium. The developed method was also validated according to International Conference on Harmonization guidelines parameters like linearity, accuracy, precision, limit of detection and quantitation. Studies were conducted to investigate different parameters involved in color developments and optimized. The pure drug of metformin was extracted from pharmaceutical dosage form. Extraction procedure was developed, and possible reaction mechanism proposed in the manuscript. The IR spectrum of the extracted metformin was taken and compared with the simulated IR spectrum obtained from the density functional theory calculation. The vibrational assignment of the modes was done based on potential energy distribution.
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Discipline
Artes, Arquitectura y UrbanismoCiencias Agrarias, Forestales y VeterinariasCiencias Exactas y NaturalesCiencias SocialesDerechoEconomía y AdministraciónFilosofía y HumanidadesIngenieríaMedicinaMultidisciplinarias
Institutions
Universidad de ChileUniversidad Católica de ChileUniversidad de Santiago de ChileUniversidad de ConcepciónUniversidad Austral de ChileUniversidad Católica de ValparaísoUniversidad del Bio BioUniversidad de ValparaísoUniversidad Católica del Nortemore

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