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dc.creatorVillarroel-Espíndola, Franz
dc.creatorMaldonado, R.
dc.creatorMancilla, H.
dc.creatorRamírez, A.
dc.creatorVander, K.
dc.creatorCereceda, K.
dc.creatorLópez, Cecilia
dc.creatorCastro, M.
dc.creatorAngulo, Constanza
dc.creatorSlebe, J.
dc.creatorConcha, Ilona
dc.date2015-12-01
dc.date.accessioned2020-10-07T22:50:21Z
dc.date.available2020-10-07T22:50:21Z
dc.identifierhttps://revistas.uautonoma.cl/index.php/ijmss/article/view/163
dc.identifier10.32457/ijmss.2015.036
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/154264
dc.descriptionSpermatogenesis is a complex physiological process that involves cell proliferation, meiotic division and a final cell differentiation of post-meiotic cells into spermatozoa. During this process male germ cells also undergo a metabolic differentiation process, in which post-meiotic spermatogenic cells (spermatids) but not meiotic spermatogenic cells (spermatocytes) respond differentially to D-glucose metabolism, glucose transporters (GLUTs) distribution and utilization of non-hexose substrates, such as lactate/pyruvate or dihydroxyacetone. These differences might be explained by the requirement for a specific metabolic process to support cell differentiation or in some cases, cell viability. In addition, though glycogen is considered to be the main glucose store, in male germ cells this polymer may play a novel role in cell proliferation, acting as a new marker for apoptotic events in testicular tissue via a yet unknown mechanism. In this article, we summarize the main metabolic changes that occur during male germ differentiation, with a specific focus on metabolic sources during spermatocyte to spermatid transition. The latter considering that these cells come from the same cell linage as specialized cells, but are not isolated from their environment, describing the roles from single molecules to polymers on the viability of male germ cells.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidad Autónoma de Chileen-US
dc.relationhttps://revistas.uautonoma.cl/index.php/ijmss/article/view/163/160
dc.rightsCopyright (c) 2020 International Journal of Medical and Surgical Sciencesen-US
dc.sourceInternational Journal of Medical and Surgical Sciences; Vol. 2 No. 4 (2015): December 2015; 603-619en-US
dc.sourceInternational Journal of Medical and Surgical Sciences; Vol. 2 Núm. 4 (2015): December 2015; 603-619es-ES
dc.source0719-532X
dc.source0719-3904
dc.subjectTestisen-US
dc.subjectCarbohydratesen-US
dc.subjectGLUTsen-US
dc.subjectGlycogenen-US
dc.subjectGlucoseen-US
dc.subjectGluconeogenesisen-US
dc.subjectSpermatogenesisen-US
dc.titleThe Many Faces of Carbohydrate Metabolism in Male Germ Cells: From Single Molecules to Active Polymersen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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