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Serum biomarkers of endothelial glycocalyx injury in canine parvoviral infection

dc.creatorNaseri, Amir
dc.creatorGulersoy, Erdem
dc.creatorIder, Merve
dc.creatorDurgut, Murat Kaan
dc.creatorErturk, Alper
dc.creatorAvci, Cagri
dc.creatorKoral, Erman
dc.creatorSevinc, Mutlu
dc.creatorOk, Mahmut
dc.date2020-10-05
dc.identifierhttp://revistas.uach.cl/index.php/australjvs/article/view/6222
dc.identifier10.4067/S0719-81322020000300095
dc.descriptionCanine parvoviral enteritis (PVE) is one of the most common diseases in young dogs. A range of diseases and inflammatory conditions can cause endothelial glycocalyx (eGCX) disruption, therefore, this study aimed to determine the presence of eGCX damage in dogs with PVE using serum biomarkers of eGCX, and to evaluate their prognostic importance among survivor and non-survivor dogs. Twenty dogs diagnosed with PVE and 10 healthy dogs of both sexes, mixed-breed, and under 6 months of age were included in the study. Clinical examination, blood gas analysis, and complete blood cell counts of the dogs were performed. To detect the eGCX injury, serum endothelial cell-specific molecule-1 (ESM-1), syndecan-1 (SDC-1), angiopoietin-2 (Ang-2), and heparan sulfate (HS) levels were measured. Results showed that at the time of admission serum levels of ESM-1 were higher in dogs with PVE compared to that of the healthy dogs. Dogs with PVE were further assigned into two groups: survivors (n:10) and non-survivors (n:10). The ESM-1 had high sensitivity and specificity to differentiate between survivor and non-survivor dogs with values of 100% and 67%, respectively, with at an optimum cut-off point of ≥460 pg/mL. We concluded that higher levels of ESM-1 in dogs with PVE may indicate eGCX injury when compared to healthy dogs. Also, the high levels of serum ESM-1 in non-survivor dogs suggest that serum ESM-1 may carry some prognostic usefulness for predicting mortality in dogs with PVE.en-US
dc.descriptionCanine parvoviral enteritis (PVE) is one of the most common diseases in young dogs. A range of diseases and inflammatory conditions can cause endothelial glycocalyx (eGCX) disruption, therefore, this study aimed to determine the presence of eGCX damage in dogs with PVE using serum biomarkers of eGCX, and to evaluate their prognostic importance among survivor and non-survivor dogs. Twenty dogs diagnosed with PVE and 10 healthy dogs of both sexes, mixed-breed, and under 6 months of age were included in the study. Clinical examination, blood gas analysis, and complete blood cell counts of the dogs were performed. To detect the eGCX injury, serum endothelial cell-specific molecule-1 (ESM-1), syndecan-1 (SDC-1), angiopoietin-2 (Ang-2), and heparan sulfate (HS) levels were measured. Results showed that at the time of admission serum levels of ESM-1 were higher in dogs with PVE compared to that of the healthy dogs. Dogs with PVE were further assigned into two groups: survivors (n:10) and non-survivors (n:10). The ESM-1 had high sensitivity and specificity to differentiate between survivor and non-survivor dogs with values of 100% and 67%, respectively, with at an optimum cut-off point of ≥460 pg/mL. We concluded that higher levels of ESM-1 in dogs with PVE may indicate eGCX injury when compared to healthy dogs. Also, the high levels of serum ESM-1 in non-survivor dogs suggest that serum ESM-1 may carry some prognostic usefulness for predicting mortality in dogs with PVE.es-ES
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dc.languageeng
dc.publisherFacultad de Ciencias Veterinarias - Universidad Austral de Chilees-ES
dc.relationhttp://revistas.uach.cl/index.php/australjvs/article/view/6222/7331
dc.rightsDerechos de autor 2020 Austral Journal of Veterinary Scienceses-ES
dc.sourceAustral Journal of Veterinary Sciences; Vol. 52 Núm. 3 (2020); 95-101en-US
dc.sourceAustral Journal of Veterinary Sciences; Vol. 52 Núm. 3 (2020); 95-101es-ES
dc.source0719-8132
dc.source0719-8000
dc.titleSerum biomarkers of endothelial glycocalyx injury in canine parvoviral infectionen-US
dc.titleSerum biomarkers of endothelial glycocalyx injury in canine parvoviral infectiones-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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