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Prevalence of HPV and EBV infection and their relationship with the p53 and PCNA expression in oral carcinoma patients

dc.creatorVeitía, Dayahindara
dc.creatorLiuzzi, Juan
dc.creatorÁvila, Maira
dc.creatorDe Guglielmo, Zoraya
dc.creatorCorrenti, María
dc.date2019-07-03
dc.date.accessioned2020-10-29T13:34:34Z
dc.date.available2020-10-29T13:34:34Z
dc.identifierhttps://revistas.udec.cl/index.php/journal_of_oral_research/article/view/894
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/155684
dc.descriptionIntroduction: Infection caused by potentially oncogenic viruses, such as HPV and EBV, favors the role of certain oncoproteins that can induce dysplasias and malignant lesions. Objective: To evaluate the prevalence of HPV and EBV and their relation with the expression of p53 and PCNA in patients with oral carcinoma. Methodology: Twenty-seven oral squamous cell carcinomas (OSCC) were evaluated; DNA extraction was conducted using the QIAamp DNA mini kit; viral detection was obtained using the INNO-LiPA kit for HPV, and nested PCR was used for EBV. The evaluation of molecular markers was performed through immunohistochemical staining. Results: The mean age of the patients was 60.55±13.94 years, and 52% of these were female. Of the patients, 59% were tobacco users and 63% were alcohol consumers. HPV was detected in 70% of the patients with the predominance of genotype 16 (60%). As for EBV infection, it was observed in 59% of cases. p53 and PCNA immunopositivity corresponded to 44% and 59%, respectively. The tongue was the anatomical location with highest positivity for both viruses as well as for the expression of molecular markers. The 48% of the cases presented infection by both viruses. es-ES
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidad de Concepción, Facultad de Odontologíaes-ES
dc.relationhttps://revistas.udec.cl/index.php/journal_of_oral_research/article/view/894/1560
dc.rightsDerechos de autor 2017 Universidad de Concepciónes-ES
dc.sourceJournal of Oral Research; Vol. 6 No. 4; 86-91en-US
dc.sourceJournal of Oral Research; Vol. 6 Núm. 4; 86-91es-ES
dc.source0719-2479
dc.source0719-2460
dc.subjectCarcinomaes-ES
dc.subjectVPHes-ES
dc.subjectVEBes-ES
dc.subjectp53es-ES
dc.subjectPCNAes-ES
dc.titlePrevalence of HPV and EBV infection and their relationship with the p53 and PCNA expression in oral carcinoma patientses-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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