| dc.creator | Mezadri, Telmo José | |
| dc.creator | Ortolan, Xana Raquel | |
| dc.date | 2019-07-09 | |
| dc.date.accessioned | 2020-10-29T13:34:36Z | |
| dc.date.available | 2020-10-29T13:34:36Z | |
| dc.identifier | https://revistas.udec.cl/index.php/journal_of_oral_research/article/view/929 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/155717 | |
| dc.description | To evaluate the osteogenic potential of chalcones using the rat critical size calvarial defect. Methods. The chalcones were synthesized from acetophenone following the Claisen-Schmidt aldol condensation method by varying the substituted benzaldehydes (3,4-Cl; 4-Cl; 4-CH3; 4-OCH3, H). The five chalcone molecules were evaluated in three concentrations (1%, 5% and 10%) in comparison to control and vehicle (Vaseline) groups. The results of the remaining wound areas were calculated statistically by the ANOVA method followed by the Student-Newman-Keuls test and the histological sections were analyzed qualitatively by light microscopy. Results. All molecules at 10% concentration showed significant bone closure compared to the control, vehicle and chalcone groups at 1% concentration (p<0.01). Active osteoblasts were observed on the repair surfaces in all groups treated with chalcones. Treatment with the C5 molecule at concentration of a 10% resulted in greater bone neoformation compared to the other molecules, with features of secondary bone observed. | es-ES |
| dc.format | application/pdf | |
| dc.language | spa | |
| dc.publisher | Universidad de Concepción, Facultad de Odontología | es-ES |
| dc.relation | https://revistas.udec.cl/index.php/journal_of_oral_research/article/view/929/1592 | |
| dc.rights | Derechos de autor 2017 Universidad de Concepción | es-ES |
| dc.source | Journal of Oral Research; Vol. 6 No. 8; 209-215 | en-US |
| dc.source | Journal of Oral Research; Vol. 6 Núm. 8; 209-215 | es-ES |
| dc.source | 0719-2479 | |
| dc.source | 0719-2460 | |
| dc.subject | chalcone | es-ES |
| dc.subject | osteogenesis | es-ES |
| dc.subject | organic synthesis | es-ES |
| dc.title | Osteogenic potential of different chalcones in an in vivo model: A preliminary study | es-ES |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
