| dc.creator | Rivera, César | |
| dc.date | 2019-07-09 | |
| dc.date.accessioned | 2020-10-29T13:34:37Z | |
| dc.date.available | 2020-10-29T13:34:37Z | |
| dc.identifier | https://revistas.udec.cl/index.php/journal_of_oral_research/article/view/939 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/155726 | |
| dc.description | The aim of this research was to identify genes, proteins and processes from the biomedical information published on recurrent aphthous stomatitis (RAS) using network-based foci. Methods: The clinical context was defined using MeSH terms for RAS and biomarkers, combined with words associated with risk. A set of protein coding genes was prioritized using the Génie web server and classified with PANTHER. For defining biologically relevant proteins, protein-protein interaction networks were constructed using Reactome database and Cytoscape. Top 20 proteins were then subjected to functional enrichment using STRING. Results: From 1,075,576 gene-abstract links, 1,491 genes were prioritized. Proteins were related to signaling molecule proteins (n=221), receptor proteins (n=221) and nucleic acid binding proteins (n=169). The network constructed with these proteins included 3,963 nodes and functional analysis showed that main processes involved immune system and zinc ion binding function. | es-ES |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Universidad de Concepción, Facultad de Odontología | es-ES |
| dc.relation | https://revistas.udec.cl/index.php/journal_of_oral_research/article/view/939/1601 | |
| dc.rights | Derechos de autor 2017 Universidad de Concepción | es-ES |
| dc.source | Journal of Oral Research; Vol. 6 No. 9; 245-251 | en-US |
| dc.source | Journal of Oral Research; Vol. 6 Núm. 9; 245-251 | es-ES |
| dc.source | 0719-2479 | |
| dc.source | 0719-2460 | |
| dc.subject | recurrent aphthous stomatitis | es-ES |
| dc.subject | pathogenesis | es-ES |
| dc.subject | protein interaction maps | es-ES |
| dc.subject | immune system | es-ES |
| dc.subject | zinc | es-ES |
| dc.title | Immune system and zinc are associated with recurrent aphthous stomatitis. An assessment using a network-based approach | es-ES |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
