Extensive studies have established a mutual association between genetic predominance and environmental factors, leading to cleft lip and palate (CLP). Currently, CLP is being treated using a multidisciplinary approach. Gene therapy has a promising future and is under development for the treatment of various diseases. What about CLP? Recently a statement denying the near future possibility of achieving a cure through somatic cell gene therapy (SCGT) was made.1 However, there is extensive research going on currently, regarding the identification of new alleles associated with CLP mutations.