CHEMICAL CHARACTERIZATION OF LIGNANS FROM ARAUCARIA ARAUCANA A NATIVE CONIFER OF CHILE AND EVALUATION OF THEIR CYTOTOXICITY AND ANTIOXIDANT ACTIVITIES

Bravo, Gaston; Torres, Solange; Figueroa, Fabian; Perez, Claudia; Paz, Cristian; Turchetti, Giovanni; Tiezzi, Antonio; Becerra, Jose

dc.creator	Bravo, Gaston
dc.creator	Torres, Solange
dc.creator	Figueroa, Fabian
dc.creator	Perez, Claudia
dc.creator	Paz, Cristian
dc.creator	Turchetti, Giovanni
dc.creator	Tiezzi, Antonio
dc.creator	Becerra, Jose
dc.date	2020-11-11
dc.date.accessioned	2021-01-29T14:14:45Z
dc.date.available	2021-01-29T14:14:45Z
dc.identifier	http://www.jcchems.com/index.php/JCCHEMS/article/view/1539
dc.identifier.uri	https://revistaschilenas.uchile.cl/handle/2250/164407
dc.description	Araucaria araucana is a native conifer of Chile commonly called Araucaria. The knots of Araucaria are extremely hard wood and highly rot-resistant, they can be found in the forest decades after that the tree has dead and decomposed. Here we report the phytochemical characterization of different parts of the Araucaria as stemwood, branch and knots, founding a remarkable difference in the content of extractables in these parts, as well as the lignan composition, which is higher in knots than in branches or stemwood. Eudesmin was isolated and crystallized from organic extract of knots, its structure was determinate by NMR; moreover, secoisolariciresinol, lariciresinol and matairesinol were identified by GCMS and HPLC in contrast to standards, and quantified in stemwood, branch and knots. The results showed that secoisolariciresinol is the main lignan with 45.77 mg g-1, followed by eudesmin with 22.68 mg g-1, lariciresinol 4.57 mg g-1 and matairesinol with 1.19 mg g-1. The antioxidant activity in terms of DPPH assay showed that knotwood extract displays the higher activity, meanwhile that eudesmin did not displays activity in DPPH assay. The cytotoxic activity against SHSY5Y neuroblastoma and P3X myeloma cell lines, revelated a moderate activity of extracts, while eudesmin did not showed activity.	en-US
dc.format	application/pdf
dc.language	eng
dc.publisher	Sociedad Chilena de Química	en-US
dc.relation	http://www.jcchems.com/index.php/JCCHEMS/article/view/1539/422
dc.rights	Copyright (c) 2020 SChQ	en-US
dc.rights	https://creativecommons.org/licenses/by-nc-sa/4.0	en-US
dc.source	Journal of the Chilean Chemical Society; Vol 65 No 4 (2020): Journal of the Chilean Chemical Society; 4953-4957	en-US
dc.source	0717-9707
dc.source	0717-9324
dc.subject	Araucaria araucana	en-US
dc.subject	lignan	en-US
dc.subject	eudesmin	en-US
dc.subject	DPPH activity	en-US
dc.subject	cytotoxic activity	en-US
dc.title	CHEMICAL CHARACTERIZATION OF LIGNANS FROM ARAUCARIA ARAUCANA A NATIVE CONIFER OF CHILE AND EVALUATION OF THEIR CYTOTOXICITY AND ANTIOXIDANT ACTIVITIES	en-US
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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