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Synthesis, Chemical Identification, Drug Release and Docking Studies of the Amlodipine–Chitosan Nanobiopolymer Composite

dc.creatorMendoza-Huizar, Luis Humberto
dc.creatorRamirez Tagle, Rodrigo
dc.creatorSalgado-Moran, Guillermo
dc.creatorLashgari , Amir
dc.creatorGhamami, Shahriar
dc.creatorCardona Villada, Wilson
dc.creatorGerli Candia, Lorena
dc.date2021-02-09
dc.date.accessioned2021-04-08T13:35:56Z
dc.date.available2021-04-08T13:35:56Z
dc.identifierhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1572
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/165119
dc.descriptionA new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all  the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttp://www.jcchems.com/index.php/JCCHEMS/article/view/1572/448
dc.rightsCopyright (c) 2021 SChQen-US
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 66 No 1 (2021): Journal of the Chilean Chemical Society; 5063-5066en-US
dc.source0717-9707
dc.source0717-9324
dc.subjectAmlodipineen-US
dc.subjectChitosanen-US
dc.subjectNanocompositeen-US
dc.subjectDrug-release propertiesen-US
dc.subjectDocking studiesen-US
dc.titleSynthesis, Chemical Identification, Drug Release and Docking Studies of the Amlodipine–Chitosan Nanobiopolymer Compositeen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


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