ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′-BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES

Demirhan, Funda; Avci Özbek, Hülya; Aydemir, Tülin; Oskay, Mustafa; Çinar, Seda

dc.creator	Demirhan, Funda
dc.creator	Avci Özbek, Hülya
dc.creator	Aydemir, Tülin
dc.creator	Oskay, Mustafa
dc.creator	Çinar, Seda
dc.date	2021-08-29
dc.date.accessioned	2021-10-04T15:10:14Z
dc.date.available	2021-10-04T15:10:14Z
dc.identifier	http://www.jcchems.com/index.php/JCCHEMS/article/view/1711
dc.identifier.uri	https://revistaschilenas.uchile.cl/handle/2250/177031
dc.description	The synthesized N,N′-bis(ferrocenylmethylene)ethylenediamine Schiff base and it’s metal complexes were screened in vitro for antimicrobial activity against two Gram-positive (Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 7064),four Gram-negative (Escherichia coli ATCC 25922, Citrobacter koseri DBCC 01, Entorebacter aeruginosa ATCC 13048,Salmonella typhimurium DBCC 02) and antifungal activity against a Candida albicans. MIC values of the compounds ranged from 27 to 533 µg/mL. Compound (5) showed very strong activity against S. aureus with the best MIC (27 µg/mL). The lowest MIC for C. albicans was obtained 107 µg/mL. The superoxide dismutase activity of Schiff base and it’s metal complexes has been measured and discussed. SOD-like activities of bis ferrocenyl Schiff base ligand metal complexes were investigated using NBT. While only the Cu (II) complex showed SOD-like (40 μm IC50) activity, the SOD-like activity value was not determined in the other complex and ligand.	en-US
dc.format	application/pdf
dc.language	eng
dc.publisher	Sociedad Chilena de Química	en-US
dc.relation	http://www.jcchems.com/index.php/JCCHEMS/article/view/1711/482
dc.rights	Copyright (c) 2021 SChQ	en-US
dc.rights	https://creativecommons.org/licenses/by-nc-sa/4.0	en-US
dc.source	Journal of the Chilean Chemical Society; Vol 66 No 3 (2021): Journal of the Chilean Chemical Society; 5237-5241	en-US
dc.source	0717-9707
dc.source	0717-9324
dc.subject	Antimicrobial activity	en-US
dc.subject	Ferrocene	en-US
dc.subject	Schiff base	en-US
dc.subject	Schiff base metal complex	en-US
dc.subject	SOD-like activity	en-US
dc.title	ANTIMICROBIAL AND SOD-LIKE ACTIVITIES OF N,N′-BIS(FERROCENYLMETHYLENE)ETHYLENEDIAMINE SCHIFF BASE AND IT’S METAL COMPLEXES	en-US
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion

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