Show simple item record

Biological and physico-mechanical properties of poly(methyl methacrylate) enriched with graphene oxide as a potential biomaterial.

Propiedades físicas-mecánicas-biológicas del poli (metilmetacrilato) enriquecido con óxido de grafeno como potencial biomaterial.

dc.creatorGarcía-Contreras, René
dc.creatorGuzmán-Juárez, Héctor
dc.creatorLópez-Ramos, Daniel
dc.creatorAlvarez-Gayosso, Carlos
dc.date2021-04-30
dc.identifierhttps://revistas.udec.cl/index.php/journal_of_oral_research/article/view/5835
dc.identifier10.17126/%x
dc.descriptionObjective: To determine the cytotoxicity and effects of graphene oxide (GO) on cellular proliferation of gingival-fibroblasts, pulpdental cells and human osteoblasts in culture, and to determine the physical, mechanical and biological properties of poly (methyl methacrylate) (PMMA) enriched with GO. Material and Methods: T he G O w as c haracterized with SEM. Cytotoxicity and cell proliferation were determined by the MTT bioassay. The physical-mechanical tests (flexural strength and elastic  modulus) were carried out with a universal testing machine. Sorption and solubility were determined by weighing before and after drying and immersion in water. Porosity was evaluated by visual inspection. Data were analyzed with Student's t-test and Tukey's post-hoc ANOVA. Results: The GO has a heterogeneous morphology and a particle size of 66.67±64.76 ?m. GO has a slight to no-cytotoxicity (>50-75% viability) at 1-30 days, and at 24 hours incubation of PMMA with GO significantly stimulates osteoblasts (45±8%, p<0.01). The physical and mechanical properties of PMMA with GO increase considerably without altering sorption, solubility and porosity. Conclusion: GO alone or with PMMA has an acceptable biocompatibility, could contribute to cell proliferation, cell regeneration and improve the physical-mechanical properties of PMMA.en-US
dc.descriptionObjective: To determine the cytotoxicity and effects of graphene oxide (GO) on cellular proliferation of gingival-fibroblasts, pulpdental cells and human osteoblasts in culture, and to determine the physical, mechanical and biological properties of poly (methyl methacrylate) (PMMA) enriched with GO. Material and Methods: T he G O w as c haracterized with SEM. Cytotoxicity and cell proliferation were determined by the MTT bioassay. The physical-mechanical tests (flexural strength and elastic  modulus) were carried out with a universal testing machine. Sorption and solubility were determined by weighing before and after drying and immersion in water. Porosity was evaluated by visual inspection. Data were analyzed with Student's t-test and Tukey's post-hoc ANOVA. Results: The GO has a heterogeneous morphology and a particle size of 66.67±64.76 ?m. GO has a slight to no-cytotoxicity (>50-75% viability) at 1-30 days, and at 24 hours incubation of PMMA with GO significantly stimulates osteoblasts (45±8%, p<0.01). The physical and mechanical properties of PMMA with GO increase considerably without altering sorption, solubility and porosity. Conclusion: GO alone or with PMMA has an acceptable biocompatibility, could contribute to cell proliferation, cell regeneration and improve the physical-mechanical properties of PMMA.es-ES
dc.formatapplication/pdf
dc.languageeng
dc.publisherUniversidad de Concepción, Facultad de Odontologíaes-ES
dc.relationhttps://revistas.udec.cl/index.php/journal_of_oral_research/article/view/5835/5544
dc.rightsDerechos de autor 2021 Universidad de Concepciónes-ES
dc.rightshttps://creativecommons.org/licenses/by/4.0/es-ES
dc.sourceJournal of Oral Research; Vol. 10 No. 2 (2021): March-April; 1-9en-US
dc.sourceJournal of Oral Research; Vol. 10 Núm. 2 (2021): Marzo-Abril; 1-9es-ES
dc.sourceJournal of Oral Research; v. 10 n. 2 (2021): Marzo-Abril; 1-9pt-BR
dc.source0719-2479
dc.source0719-2460
dc.titleBiological and physico-mechanical properties of poly(methyl methacrylate) enriched with graphene oxide as a potential biomaterial.en-US
dc.titlePropiedades físicas-mecánicas-biológicas del poli (metilmetacrilato) enriquecido con óxido de grafeno como potencial biomaterial.es-ES
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record