This study described the existent relationship between self-efficacy, self-esteem and assertiveness, and between these three variables and academic performance, in 43 students of both sexes, who started in 2010, the career of Occupational Therapy at the University San Sebastian, in Santiago de Chile. As a quantitative research, with a non-experimental and correlational design, it had the longing to establish relations between variables in study, but without determining causality between them. To this end, the procedures used were the evaluation with three self-administrated tests, as data collection instruments, that specifically measured levels of self-esteem, assertiveness and self-efficacy (Coopersmith self-esteem inventory, Rathus assertiveness scale and Scale of generalized self-efficacy); with its subsequent tabulation. Besides, was considered the score average obtained by these students in the first year of their career. The analysis of these results showed that there is a significant correlation between the variables self-esteem, assertiveness and self-efficacy; but not as well between these and academic performance. Although, was verified a relation between these variables but not the extent of it. It is hypothesized about the possible explanations for these results, and suggestions are provided.Se presentan los resultados de investigación de un estudio correlacional, realizado con una muestra de los estudiantes de ingreso en 2010, a la carrera Terapia Ocupacional, de la Universidad San Sebastián, en su sede de Santiago. Se establecen las relaciones entre autoestima, asertividad y autoeficacia, así como la vinculación de éstas con rendimiento académico. Se concluye que existe una correlación significativa entre las variables autoestima, asertividad y autoeficacia; pero no así entre éstas y rendimiento académico, pudiéndose verificar solamente una vinculación entre ellas, pero sin determinar el grado de la misma. Se hipotetiza al respecto de las posibles explicaciones de estos resultados y se contribuye con sugerencias metodológicas, para aportar al desarrollo profesional de los futuros terapeutas ocupacionales.