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dc.creatorROJO,DANIEL
dc.creatorSUETOMI,KATSUTOSHI
dc.creatorNAVARRO,JAVIER
dc.date1999-01-01
dc.date.accessioned2022-08-29T19:34:34Z
dc.date.available2022-08-29T19:34:34Z
dc.identifierhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97601999000400006
dc.identifier.urihttps://revistaschilenas.uchile.cl/handle/2250/206216
dc.descriptionChemokine receptors are G protein-coupled receptors that mediate migration and activation of leukocytes as an important part of a protective immune response to injury and infection. In addition, chemokine receptors are used by HIV-1 to infect CD4 positive cells. The structural bases of chemokine receptor recognition and signal transduction are currently being investigated. High-resolution X-ray diffraction and NMR spectroscopy of chemokines indicate that all these peptides exhibit a common folding pattern, in spite of its low degree of primary-sequence homology. Chemokines' functional motifs have been identified by mutagenesis studies, and a possible mechanism for receptor recognition and activation is proposed, but high-resolution structure data of chemokine receptors is not yet available. Studies with receptor chimeras have identified the putative extracellular domains as the major selectivity determinants. Single-amino acid substitutions in the extracellular domains produce profound changes in receptor specificity, suggesting that motifs in these domains operate as a restrictive barrier to a common activation motif. Similarly HIV-1 usage of chemokine receptors involves interaction of one or more extracellular domains of the receptor with conserved and variable domains on the viral envelope protein gp 120, indicating a highly complex interaction. Elucidating the structural requirements for receptor interaction with chemokines and with HIV-1 will provide important insights into understanding the mechanisms of chemokine recognition and receptor activation. In addition, this information can greatly facilitate the design of effective inmunomodulatory and anti-HIV-1 therapeutic agents
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dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97601999000400006
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.32 n.4 1999
dc.subjectChemokines
dc.subjectG-protein coupled receptors
dc.subjectInflammation
dc.subjectHIV-1
dc.titleStructural biology of chemokine receptors


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