By analyzing the highlights of the major activities reported by the technology transfer offices (TTOs) of twenty US major universities, the performances of TTO activities are quantitatively assessed and the associated scores are compared with each other. The key performance indicators, which govern the success of the university technology transfer, are specifically selected and examined. Two normalized metrics, overall performance metric (OPM) and patenting control ratio (PCR), which are the representing combined indicators for the TTO performance, are developed and demonstrated. The two metrics are evaluated for each university selected and compared to specifically provide a comprehensive overview of how good is the TTO of a university as compare to those of its peers. Finally, the factors for a successful TTO are described and the major unsolved issues are also discussed.