This article has the purpose of developing a framework for management of knowledge and technology transfer in Brazilian academic internships, with a Knowledge Management approach. The methodological procedures employed are classified as qualitative, bibliographical, documentary, and a survey, having academic internships in Brazil as the object of study. The framework proposed is an advantage in internship management, systematizing information, knowledge, and technology, in addition to increasing the potential of internship activities. The framework for management of knowledge and technology transfer in Brazilian academic internships offers its users not only a service of knowledge management, but also a Knowledge Management System with resources of Communication and Information Technology for the construction of a learning platform, in which coordinators, professors, supervisors, and student-interns would be able to manage the internship, its activities, and the online learning environment. In other words, it is an environment designed for the development of academic knowledge in professional capacities.