Article in Spanish The challenge of manage the scientific knowledge The optimal commercialization of scientific findings is an interesting issue to several technology managers and also to developers of public policies. This implies a special challenge due unfortunately to the not necessarily the good scientific ideas are translated to business. To achieve this, researchers in the future must have skills in science, technology and finances, to confront the demands and requirements projected ina a knowledge based economy.Artículo en Español La comercialización óptima de hallazgos científicos es un tema de interés para muchos gestores tecnológicos en el mundo y también para quienes desarrollan políticas públicas. Lo anterior implica un especial desafío debido a que por desgracia, las buenas ideas científicas no necesariamente se traducen en buenos negocios. Para lograr esto, los futuros investigadores deberán tener a su disposición una mezcla de ciencia, tecnología y finanzas para afrontar las demandas y requerimientos que se proyectan en una economía basada en el conocimiento.Article in Spanish The challenge of manage the scientific knowledge The optimal commercialization of scientific findings is an interesting issue to several technology managers and also to developers of public policies. This implies a special challenge due unfortunately to the not necessarily the good scientific ideas are translated to business. To achieve this, researchers in the future must have skills in science, technology and finances, to confront the demands and requirements projected ina a knowledge based economy.