In June 2020 appeared the first cases of Multisystem Inflammatory Syndrome in Children (MISC) associated with COVID-19 in Chile. Possible sequelae associated with this condition are still unknown. Objective: To describe the functional status of children with MIS-C admitted to a high complexity Hospital. Patients and Method: Descriptive, prospective study. Sample of 28 patients. The functional status was evaluated during Hospitalization, and in the first and fourth months after discharge with the Functional Status Scale (FSS), Pediatric Evaluation of Disability Inventory (PEDICAT), 6-minute walk test (6MWT), PImax and PEmax, and dynamometry. Post-Traumatic Stress Disorder was screened with the Child PTSD Symptom Scale (CPSS). Results: Mean age 63.6 months. Sixteen were women and 60.7% presented no comorbidities. Half of the cases presented with Shock. Mean hospitalization was 9 days. Twenty-two patients were admitted to the ICU; 54% required mechanical ventilation and/or vasoactive drugs, and 82% had cardiac repercussions. During hospitalization, 82.3% presented some physical alteration, 29.1% of them were confirmed ICU-acquired weakness (ICU-AW), and 16.6% were suspected cases. Thirteen patients presented emotional symptoms, 39.2% had post-ICU syndrome. Most of the patients (58.8%) had an unfavorable Functional Situation and recovered 4 months post-discharge. All patients reversed echocardiographic abnormalities in the first month and regained muscle strength in the fourth month. 38.5% of subjects reported suboptimal values in the 6MWT and 66.6% presented alteration in the post-traumatic stress screening. Conclusion: Most of the patients presented functional compromise with favorable recovery despite the severity of the symptoms and possible secondary complications after ICU.En junio 2020, se reportaron casos de Síndrome Inflamatorio Multisistémico Pediátrico asociado a COVID-19 (SIM-C) en Chile, aún se desconocen las posibles secuelas. Objetivo: Describir el estado funcional de niños con SIM-C ingresados a un hospital de alta complejidad. Pacientes y Método: Estudio descriptivo, prospectivo. Muestra de 28 pacientes. El estado funcional se evaluó en: Hospitalización, primer y cuarto mes post alta, con: Functional Status Scale (FSS), Pediatric Evaluation of Disability Inventory (PEDI-CAT), Test de marcha en 6 minutos (TM6M), Pimometría y dinamometría. El Trastorno de Estrés Postraumático se pesquisó con Child PTSD Symptom Scale (CPSS). Resultados: Mediana de edad: 63,6 meses. Dieciséis eran mujeres y 60,7% sin comorbilidades previas. El 50% de los casos se presentó con Shock. Mediana de hospitalización: 9 días. El 78% ingresó a UCI; 54% requirió ventilación mecánica y/o drogas vasoactivas, 82% tuvo compromiso cardíaco. En la hospitalización: 82,3% presentó alteraciones físicas: 29,1% debilidad adquirida en UCI (DAUCI) confirmada y 16,6% sospecha. Trece niños presentaron síntomas emocionales, 39,2% síndrome post UCI. El 58,8% tuvo una Situación Funcional desfavorable, recuperada al cuarto mes post alta. Todos los pacientes presentaron hallazgos esperables para su edad en ecocardiogramas del primer mes y en fuerza muscular al cuarto mes. El 38,5% de sujetos reportó valores subóptimos en el TM6M y el 66,6% presentó alteración del tamizaje de estrés post traumático. Conclusión: La mayoría presentó compromiso funcional con recuperación favorable, pese a la gravedad del cuadro y eventuales complicaciones secundarias post UCI.