Following an increasing body of literature that has been generated regarding the role played by Knowledge Intensive Services in economic systems, our approach focuses on KIS international orientation (FDI) according to the attractiveness we expect Regional Innovation Systems might have in these flows. Results suggest that technological variables participate rather marginally in the process of FDI attraction. As this situation unfolds more relevantly in the case of Outward investment than Inward, we can therefore expect that Spanish investment abroad is more oriented towards asset and knowledge seeking than the inflow of investments in services and in KIS in Spanish regions.