Organizational Culture is widely recognized as one of the fundamental elements for the successful implementation of Total Quality Management, which is not always easy to harmonize. Therefore, it is necessary to promote the development and commitment of workers towards quality and productivity. The purpose of this work is to analyze the correlation between Organizational Culture and the implementation of Total Quality Management practices through an empirical study in small and medium-sized companies in the clothing industry in the state of Tlaxcala,Mexico. The study is quantitative and cross-sectional  through the application of the Competence Values Framework to assess Organizational Culture and the model of the European Foundation for Quality Management to examine Total Quality Management. The information was obtained through a survey addressed to executives of the participating companies, and the data analyzed through descriptive statistics, Pearson’s correlation, and simple regression analysis. The findings support a positive correlation between Organizational Culture and the implementation of Total Quality Management practices. The limitations of this study are its sectoral nature and the fact that it is restricted to a specific territory.La Cultura Organización es ampliamente reconocida como uno de los elementos fundamentales para la implementación exitosa de la Gestión de la Calidad Total, lo cual, no siempre es fácil armonizarlas. El propósito de este trabajo es evaluar la relación entre la Cultura Organizacional y Gestión de la Calidad Total mediante un estudio empírico en las pequeñas y medianas empresas de la industria del vestido del estado de Tlaxcala, México. Se desarrollo un estudio cuantitativo y transversal a través de un cuestionario dirigido a empresarios y gerentes de las PyMES de una muestra de 58 pequeñas y 11 medianas empresas. Se evidencia la relación existente entre la Cultura Organizacional y implementación de la Gestión de la Calidad Total. Las limitaciones de este estudio es su carácter sectorial y está restringido a un territorio específico.