The objective of this study is to determine optimum parameters for double dowels in medium density fiberboard components, and the maximum value of the strength of joints loaded in tension and compression bending. This study analyzes dowel diameter, clearance or interference fit value, and dowel spacing by using the orthogonal experiment method. Optimum parameters for double dowels in medium density fiberboard component structures were obtained by orthogonal experiment and verified by simulation using ANSYS finite element analysis software. Experimental and simulation-based results revealed that the optimal parameters for double dowel joints with maximum tensile strength were a dowel diameter of 10.00mm, an interference fit of 0.20mm, and a spacing of 64.00mm.The optimal parameters for double dowel joints with maximum bending strength were a dowel diameter of 10.00mm, an interference fit of 0.10mm, and a spacing of 48.00mm.