Gene expression of collagen type I alpha 2 and its relationship with dental fluorosis.
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| dc.creator | Gastelbondo-Pastrana, Bertha | |
| dc.creator | Madera Anaya, Meisser Vidal | |
| dc.creator | Suárez-Causado, Amileth | |
| dc.date | 2018-07-30 | |
| dc.identifier | http://www.joralres.com/index.php/JOR/article/view/joralres.2018.056 | |
| dc.identifier | 10.17126/joralres.2018.056 | |
| dc.description | Objective: To compare the gene expression levels of collagen type I alpha 2 (COL1A2) in children with and without dental fluorosis. Methods: Cross-sectional study involving 92 children between 5 and 12 years of age. Socio-demographic characteristics, the presence of dental fluorosis by means of the Thylstrup-Fejerskov index, and gene expression analysis of COL1A2 in peripheral blood samples by reverse transcription polymerase chain reaction (RT-PCR) assays, were described. For the descriptive analysis, measures of central tendency, dispersion and proportions were used. Differences between the groups (p<0.05) were established by the Student t-test. Results: Mean age was 8.6 (SD=1.9) years, 51.1% were female; 54 children were diagnosed with fluorosis and 38 without fluorosis; prevalence of dental fluorosis was 58.7% (95% CI: 48.4% -68.9%). Gene expression of COL1A2 was statistically significantly lower (p<0.05) in the participants with dental fluorosis. Conclusion: There are differences in the expression levels of the COL1A2 gene among the population under study. Therefore, COL1A2 may be potentially involved in the development of dental fluorosis. | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Facultad de Odontología, Universidad de Concepción, Chile. | en-US |
| dc.relation | http://www.joralres.com/index.php/JOR/article/view/joralres.2018.056/458 | |
| dc.source | Journal of Oral Research; Vol 7 No 6; 232-235 | es-ES |
| dc.source | Journal of Oral Research; Vol 7 No 6; 232-235 | en-US |
| dc.source | 0719-2479 | |
| dc.source | 0719-2460 | |
| dc.subject | dental fluorosis; dental enamel; gene expression; collagen. | en-US |
| dc.title | Gene expression of collagen type I alpha 2 and its relationship with dental fluorosis. | en-US |
| dc.title | es-ES | |
| dc.title | pt-BR | |
| dc.title | pt-PT | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | Communication | en-US |
This item appears in the following Collection(s)
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Journal of Oral Research
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