La rinosinusitis fúngica invasiva aguda es una entidad infecciosa poco frecuente, con alta mortalidad (50-80%), caracterizada por angioinvasión primaria, trombosis, isquemia y necrosis. Puede deberse a hongos Zygomycetes (como el Mucor) y Aspergillus. Se ve en pacientes con inmunocompromiso como diabéticos mal controlados, neoplasias hematológicas, régimen quimioterápico, síndrome de inmunodeficiencia adquirida y trasplantados. Se presenta un caso de Mucormicosis RinoOrbito-Cerebral en una paciente con antecedente de Síndrome de Dificultad Respiratoria Severa por el Nuevo Coronavirus y posteriormente se revisa la literatura pertinente.Acute invasive fungal rhinosinusitis is a rare infectious condition with high mortality rates (50- 80%), characterized by primary angioinvasion, thrombosis, ischemia, and necrosis. It can be caused by Zygomycetes fungi (such as Mucor) and Aspergillus. It is observed in immunocompromised patients, such as poorly controlled diabetics, hematologic malignancies, undergoing chemotherapy, acquired immunodeficiency syndrome, and transplant recipients. This case report presents a case of Rhino-Orbito-Cerebral Mucormycosis in a patient with a history of Severe Acute Respiratory Syndrome due to the novel coronavirus, followed by a review of the relevant literature.