| dc.creator | Veitía, Dayahindara | |
| dc.creator | Liuzzi, Juan | |
| dc.creator | Àvila, Maira | |
| dc.creator | De Guglielmo, Zoraya | |
| dc.creator | Correnti, María | |
| dc.date | 2017-04-25 | |
| dc.identifier | http://www.joralres.com/index.php/JOR/article/view/joralres.2017.026 | |
| dc.identifier | 10.17126/joralres.2017.026 | |
| dc.description | Introduction: Infection caused by potentially oncogenic viruses, such as HPV and EBV, favors the role of certain oncoproteins that can induce dysplasias and malignant lesions. Objective: To evaluate the prevalence of HPV and EBV and their relation with the expression of p53 and PCNA in patients with oral carcinoma. Methodology: Twenty-seven oral squamous cell carcinomas (OSCC) were evaluated; DNA extraction was conducted using the QIAamp DNA mini kit; viral detection was obtained using the INNO-LiPA kit for HPV, and nested PCR was used for EBV. The evaluation of molecular markers was performed through immunohistochemical staining. Results: The mean age of the patients was 60.55±13.94 years, and 52% of these were female. Of the patients, 59% were tobacco users and 63% were alcohol consumers. HPV was detected in 70% of the patients with the predominance of genotype 16 (60%). As for EBV infection, it was observed in 59% of cases. p53 and PCNA immunopositivity corresponded to 44% and 59%, respectively. The tongue was the anatomical location with highest positivity for both viruses as well as for the expression of molecular markers. The 48% of the cases presented infection by both viruses. Conclusion: HPV and EBV infection together with the expression of p53 and PCNA were more frequently observed in advanced stages of the disease, suggesting a more relevant role in the progression than in tumor genesis. | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Facultad de Odontología, Universidad de Concepción, Chile. | en-US |
| dc.relation | http://www.joralres.com/index.php/JOR/article/view/joralres.2017.026/301 | |
| dc.source | Journal of Oral Research; Vol 6 No 4; 86-91 | es-ES |
| dc.source | Journal of Oral Research; Vol 6 No 4; 86-91 | en-US |
| dc.source | 0719-2479 | |
| dc.source | 0719-2460 | |
| dc.subject | Carcinoma; VPH; VEB; p53; PCNA. | en-US |
| dc.title | Prevalence of HPV and EBV infection and their relationship with the p53 and PCNA expression in oral carcinoma patients. | en-US |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | Articles | en-US |
