| dc.creator | Ortolan, Xana Raquel | |
| dc.creator | Mezadri, Telmo José | |
| dc.creator | Tames, David Rivero | |
| dc.creator | Corrêa, Rogério | |
| dc.creator | Campos-Buzzi, Fátima | |
| dc.date | 2017-08-24 | |
| dc.identifier | http://www.joralres.com/index.php/JOR/article/view/joralres.2017.059 | |
| dc.identifier | 10.17126/joralres.2017.059 | |
| dc.description | Aim. To evaluate the osteogenic potential of chalcones using the rat critical size calvarial defect. Methods. The chalcones were synthesized from acetophenone following the Claisen-Schmidt aldol condensation method by varying the substituted benzaldehydes (3,4-Cl; 4-Cl; 4-CH3; 4-OCH3, H). The five chalcone molecules were evaluated in three concentrations (1%, 5% and 10%) in comparison to control and vehicle (Vaseline) groups. The results of the remaining wound areas were calculated statistically by the ANOVA method followed by the Student - Newman - Keuls test and the histological sections were analyzed qualitatively in by light microscopy. Results. All molecules at 10% concentration showed significant bone closure compared to the control, vehicle and chalcone groups at 1% concentration (p<0.01). Active osteoblasts were observed on the repair surfaces in all groups treated with chalcones. Treatment with the C5 molecule at concentration of 10% resulted in greater bone neoformation compared to the other molecules, with features of secondary bone observed. Conclusion. The chalcones evidenced a dose-dependent osteogenic potential and C5 was more effective in bone repair. | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Facultad de Odontología, Universidad de Concepción, Chile. | en-US |
| dc.relation | http://www.joralres.com/index.php/JOR/article/view/joralres.2017.059/333 | |
| dc.source | Journal of Oral Research; Vol 6 No 8; 209-215 | es-ES |
| dc.source | Journal of Oral Research; Vol 6 No 8; 209-215 | en-US |
| dc.source | 0719-2479 | |
| dc.source | 0719-2460 | |
| dc.subject | chalcone; osteogenesis; organic synthesis. | en-US |
| dc.title | Osteogenic potential of different chalcones in an in vivo model: A preliminary study. | en-US |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | Articles | en-US |
