| dc.creator | Richter, Pablo | |
| dc.date | 2023-01-09 | |
| dc.date.accessioned | 2024-11-19T14:36:00Z | |
| dc.date.available | 2024-11-19T14:36:00Z | |
| dc.identifier | http://www.jcchems.com/index.php/JCCHEMS/article/view/2219 | |
| dc.identifier.uri | https://revistaschilenas.uchile.cl/handle/2250/246261 | |
| dc.description | Ibuprofen is one of the most widely used nonsteroidal anti-inflammatory drugs due to its analgesic, anti-inflammatory and antipyretic properties, as well as its low cost and easy accessibility. A fraction of the compound and its metabolites are excreted in the urine, being eliminated in the wastewater reaching river waters in the range of ng L-1 to µg L-1. In this context, highly sensitive and selective analytical methods are required to quantify them, including these methods a pre-concentration step. In this work, the use of a microextraction technology based on rotating-disk sorptive extraction, involving a sorptive phase of laminar cork, was implemented for the extraction of ibuprofen and 1-hydroxyibuprofen from aqueous samples and their subsequent determination by gas chromatography coupled to mass spectrometry. The optimal conditions for determination of the analytes were: 20 mL of sample volume, pH 2, 20 % w/v NaCl (to increase the ionic strength), 90 min of extraction time and 2000 rpm of rotation velocity of the disk. Recoveries of 118 and 39 % and relative standard deviations of 6 and 13 % for ibuprofen and 1-hydroxyibuprofen were obtained, respectively. The presence of both compounds in river waters (Mapocho River, Santiago de Chile) at a concentration of 2.56 to 4.08 µg L-1 were found. The use of laminar cork as a natural sorbent phase immobilized in the rotating-disk allowed to extract the analytes from water samples through its lipophilic-hydrophilic balance that favors the interaction with the compounds under study.
| en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Sociedad Chilena de Química | en-US |
| dc.relation | http://www.jcchems.com/index.php/JCCHEMS/article/view/2219/572 | |
| dc.rights | Copyright (c) 2023 SChQ | en-US |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/4.0 | en-US |
| dc.source | Journal of the Chilean Chemical Society; Vol 67 No 4 (2022): Journal of the Chilean Chemical Society; 5722-5726 | en-US |
| dc.source | 0717-9707 | |
| dc.source | 0717-9324 | |
| dc.subject | Cork, ibuprofen, 1-hydroxyibuprofen, natural sorptive phase, RDSE. | en-US |
| dc.title | DETERMINATION OF IBUPROFEN AND 1-HYDROXYIBUPROFEN IN AQUEOUS SAMPLES USING CORK AS A NATURAL PHASE IN ROTATING-DISK SORPTIVE EXTRACTION | en-US |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
