Background: In Mexico, there is no available instrument based on a biopsychosocial model to evaluate the impact of periodontal disease on oral health- related quality of life (OHRQL). The Oral Health Impact Profile (OHIP-14) was developed in Australia and the United States based on the same model and can be adapted to evaluate the impact of periodontal disease on OHRQL. Objectives: To adapt the OHIP-14 questions to periodontal disease evaluation and validate the content of this new instrument. Materials and Methods: One expert in periodontics and one expert in health psychology adapted the OHIP-14 to evaluate the impact of periodontal disease on OHRQL, creating the Oral Health Impact Profile applied to Periodontal Disease (OHIP-14-PD). Using the format proposed by Escobar and Cuervo, five experts in periodontics and public health performed the OHIP-14-PD content validation. Results: Item 7 had a compliance rate of 80% for clarity, and the other items, a compliance rate of 100%, for clarity, sufficiency, coherence and relevance. The kappa coefficient showed perfect agreement for items 1 to 6 (k= 1) and 8 to 14, and very high agreement for item 7 (k= 0.967). Conclusion: The OHIP-14-PD shows content validity.