Managing the collective knowledge of individuals has been a dominant business theme for decades, and numerous organizations have launched knowledge management (KM) or innovation-oriented initiatives. This research builds on prior theoretical work on how an organization’s culture and structure influence its KM programs. A 16-item innovation culture index is developed and tested on a large non-profit organization to provide senior managers with empirical evidence that offers an initial baseline assessment of organizational innovativeness and metrics for evaluating continuous improvement efforts.