Considering the possible impacts of technostress on individuals and organizations and the remote work regime imposed on education employees during the pandemic that intensified the use of technologies, the aim of this paper was to analyze underlying factors related to role ambiguity, their effects and forms of mitigation. The final sample is comprised of 691 complete responses. The data were collected electronically between August, 2021 and November, 2021. To test the study hypotheses, we adopted the Structural Equation Modeling. According to the main results, Computer Self-Efficacy can mitigate the effects of Role Ambiguity and, indirectly, Computer Self-Efficacy also has a negative effect on Cognitive Load. We also observed that Role Ambiguity presented a positive effect on Cognitive Load. The variable Resilience moderated the relationships: i) between Computer Self-Efficacy and Role Ambiguity; and ii) between Role Ambiguity and Cognitive Load.